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[HTML][HTML] Enterovirus A71 antivirals: past, present, and future
Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …
[HTML][HTML] Targeting viral entry as a strategy for broad-spectrum antivirals
M Mazzon, M Marsh - F1000Research, 2019 - ncbi.nlm.nih.gov
The process of entry into a host cell is a key step in the life cycle of most viruses. In recent
years, there has been a significant increase in our understanding of the routes and …
years, there has been a significant increase in our understanding of the routes and …
C-2 thiophenyl tryptophan trimers inhibit cellular entry of SARS-CoV-2 through interaction with the viral spike (S) protein
M Gargantilla, C Francés, A Adhav… - Journal of Medicinal …, 2023 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, by
infecting cells via the interaction of its spike protein (S) with the primary cell receptor …
infecting cells via the interaction of its spike protein (S) with the primary cell receptor …
[HTML][HTML] Advances in anti-EV-A71 drug development research
Abstract Background Enterovirus A71 (EV-A71) is capable of causing hand, foot and mouth
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …
Antivirals blocking entry of enteroviruses and therapeutic potential
Viruses from the genus Enterovirus (EV) of the Picornaviridae family are known to cause
diseases such as hand foot and mouth disease (HFMD), respiratory diseases, encephalitis …
diseases such as hand foot and mouth disease (HFMD), respiratory diseases, encephalitis …
Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors
ABSTRACT Enterovirus A71 (EV-A71), a positive-stranded RNA virus of the Picornaviridae
family, may cause neurological complications or fatality in children. We examined specific …
family, may cause neurological complications or fatality in children. We examined specific …
Evaluation of 3D human intestinal organoids as a platform for EV-A71 antiviral drug discovery
F Masmoudi, N Santos-Ferreira, D Pajkrt, KC Wolthers… - Cells, 2023 - mdpi.com
Enteroviruses are a leading cause of upper respiratory tract, gastrointestinal, and
neurological infections. Management of enterovirus-related diseases has been hindered by …
neurological infections. Management of enterovirus-related diseases has been hindered by …
Dendrimer as nanocarrier for drug delivery and drug targeting therapeutics: a fundamental to advanced systematic review
Abstract Development of novel nano therapeutic material is of great interest among the
researchers and with continuous advancement in nanotechnology, dendrimer a …
researchers and with continuous advancement in nanotechnology, dendrimer a …
Multiplexed multicolor antiviral assay amenable for high-throughput research
To curb viral epidemics and pandemics, antiviral drugs are needed with activity against
entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay …
entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay …
Spike glycoproteins: Their significance for corona viruses and receptor binding activities for pathogenesis and viral survival
The recent outbreak of Covid-19 is posing a severe threat to public health globally.
Coronaviruses (CoVs) are the largest known group of positive-sense RNA viruses surviving …
Coronaviruses (CoVs) are the largest known group of positive-sense RNA viruses surviving …