[HTML][HTML] Enterovirus A71 antivirals: past, present, and future

J Wang, Y Hu, M Zheng - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Enterovirus A71 (EV-A71) is a significant human pathogen, especially in children.
EV-A71 infection is one of the leading causes of hand, foot, and mouth diseases (HFMD) …

[HTML][HTML] Targeting viral entry as a strategy for broad-spectrum antivirals

M Mazzon, M Marsh - F1000Research, 2019 - ncbi.nlm.nih.gov
The process of entry into a host cell is a key step in the life cycle of most viruses. In recent
years, there has been a significant increase in our understanding of the routes and …

C-2 thiophenyl tryptophan trimers inhibit cellular entry of SARS-CoV-2 through interaction with the viral spike (S) protein

M Gargantilla, C Francés, A Adhav… - Journal of Medicinal …, 2023 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, by
infecting cells via the interaction of its spike protein (S) with the primary cell receptor …

[HTML][HTML] Advances in anti-EV-A71 drug development research

S Wang, Z Pang, H Fan, Y Tong - Journal of Advanced Research, 2024 - Elsevier
Abstract Background Enterovirus A71 (EV-A71) is capable of causing hand, foot and mouth
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …

Antivirals blocking entry of enteroviruses and therapeutic potential

MI Anasir, F Zarif, CL Poh - Journal of Biomedical Science, 2021 - Springer
Viruses from the genus Enterovirus (EV) of the Picornaviridae family are known to cause
diseases such as hand foot and mouth disease (HFMD), respiratory diseases, encephalitis …

Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors

CF Hsieh, JR Jheng, GH Lin, YL Chen… - Emerging Microbes & …, 2020 - Taylor & Francis
ABSTRACT Enterovirus A71 (EV-A71), a positive-stranded RNA virus of the Picornaviridae
family, may cause neurological complications or fatality in children. We examined specific …

Evaluation of 3D human intestinal organoids as a platform for EV-A71 antiviral drug discovery

F Masmoudi, N Santos-Ferreira, D Pajkrt, KC Wolthers… - Cells, 2023 - mdpi.com
Enteroviruses are a leading cause of upper respiratory tract, gastrointestinal, and
neurological infections. Management of enterovirus-related diseases has been hindered by …

Dendrimer as nanocarrier for drug delivery and drug targeting therapeutics: a fundamental to advanced systematic review

V Rastogi, P Yadav, M Porwal, S Sur… - International Journal of …, 2024 - Taylor & Francis
Abstract Development of novel nano therapeutic material is of great interest among the
researchers and with continuous advancement in nanotechnology, dendrimer a …

Multiplexed multicolor antiviral assay amenable for high-throughput research

LH Li, W Chiu, YA Huang, M Rasulova… - Nature …, 2024 - nature.com
To curb viral epidemics and pandemics, antiviral drugs are needed with activity against
entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay …

Spike glycoproteins: Their significance for corona viruses and receptor binding activities for pathogenesis and viral survival

A Noman, M Aqeel, N Khalid, M Hashem… - Microbial …, 2021 - Elsevier
The recent outbreak of Covid-19 is posing a severe threat to public health globally.
Coronaviruses (CoVs) are the largest known group of positive-sense RNA viruses surviving …