Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Renal cell carcinoma (RCC) is the most common type of kidney cancer and comprises
several subtypes with unique characteristics. The most common subtype (~ 70% of cases) is …

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …

Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

AIM To investigate the clinical significance of preoperative systemic immune-inflammation
index (SII) in patients with colorectal cancer (CRC). METHODS A retrospective analysis of …

Immunological niches are focal sites of immune activity that can have varying
microenvironmental features. Hypoxia is a feature of physiological and pathological …

The role of adaptive immunity in early cancer development is controversial. Here we show
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …