Although significant advances have been made in recent years, the structural elucidation of
small molecules continues to remain a challenging issue for metabolite profiling. Many …

The intestine and liver are thought to metabolize dietary nutrients and regulate host nutrient
homeostasis. Here, we find that the gut microbiota also reshapes the host amino acid (aa) …

The intestinal microbiota undergoes diurnal compositional and functional oscillations that
affect metabolic homeostasis, but the mechanisms by which the rhythmic microbiota …

Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of
resistance remain poorly defined. We used a series of whole-genome clustered regularly …

Tissue macrophages provide immunological defense and contribute to the establishment
and maintenance of tissue homeostasis. Here we used constitutive and inducible …

Metabolomics research often requires the use of multiple analytical platforms, batches of
samples, and laboratories, any of which can introduce a component of unwanted variation …

Management of metabolic hydrogen ([H]) in the rumen has been identified as an important
consideration when reducing ruminant CH4 emissions. However, little is known about …

Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone
marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic …

Epidermal bladder cells (EBCs) have been postulated to assist halophytes in co** with
saline environments. However, little direct supporting evidence is available. Here …

Metabolomics represents an emerging and powerful discipline that provides an accurate
and dynamic picture of the phenotype of biosystems through the study of potential …