Understanding RAGE, the receptor for advanced glycation end products

A Bierhaus, PM Humpert, M Morcos, T Wendt… - Journal of molecular …, 2005 - Springer
Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-β
peptides, and the family of β-sheet fibrils have been shown to contribute to a number of …

Advanced glycation endproducts in food and their effects on health

MW Poulsen, RV Hedegaard, JM Andersen… - Food and Chemical …, 2013 - Elsevier
Advanced glycation endproducts (AGEs) form by Maillard-reactions after initial binding of
aldehydes with amines or amides in heated foods or in living organisms. The mechanisms of …

Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein

JS Park, D Svetkauskaite, Q He, JY Kim… - Journal of Biological …, 2004 - ASBMB
High mobility group box 1 (HMGB1) protein, originally described as a DNA-binding protein
that stabilizes nucleosomes and facilitates transcription, can also be released extracellularly …

Pathophysiology of RAGE in inflammatory diseases

H Dong, Y Zhang, Y Huang, H Deng - Frontiers in Immunology, 2022 - frontiersin.org
The receptor for advanced glycation end products (RAGE) is a non-specific multi-ligand
pattern recognition receptor capable of binding to a range of structurally diverse ligands …

Cellular signalling of the receptor for advanced glycation end products (RAGE)

J **e, JD Méndez, V Méndez-Valenzuela… - Cellular signalling, 2013 - Elsevier
The receptor for advanced glycation end-product (RAGE) is the signal transduction receptor
which senses a variety of signalling molecules including advanced glycation end products …

Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications

R Ramasamy, SF Yan… - Annals of the New York …, 2011 - Wiley Online Library
The receptor for advanced glycation endproducts (RAGE) was first described as a signal
transduction receptor for advanced glycation endproducts (AGEs), the products of …

RAGE regulation and signaling in inflammation and beyond

K Kierdorf, G Fritz - Journal of leukocyte biology, 2013 - academic.oup.com
ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …

Targeting the receptor for advanced glycation endproducts (RAGE): a medicinal chemistry perspective

S Bongarzone, V Savickas, F Luzi… - Journal of medicinal …, 2017 - ACS Publications
The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …

Scavenger receptor structure and function in health and disease

I Abdul Zani, SL Stephen, NA Mughal, D Russell… - Cells, 2015 - mdpi.com
Scavenger receptors (SRs) are a 'superfamily'of membrane-bound receptors that were
initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is …

Redox signaling and advanced glycation endproducts (AGEs) in diet-related diseases

V Cepas, M Collino, JC Mayo, RM Sainz - Antioxidants, 2020 - mdpi.com
Diets are currently characterized by elevated sugar intake, mainly due to the increased
consumption of processed sweetened foods and drinks during the last 40 years. Diet is the …