Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and
mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is …

Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

Abstract Rationale: Breast cancer (BC), as one of the most frequently diagnosed cancer, has
a poor prognosis due to the development of distant metastasis. Among the BC metastatic …

The complex and adaptive nature of malignant neoplasm constitute a major challenge for
the development of effective anti-oncogenic therapies. Emerging evidence has uncovered …

Breast cancer is a complex, dynamic disease that acquires heterogeneity through various
mechanisms, allowing cancer cells to proliferate, survive and metastasise. Heterogeneity is …

Background Bone metastasis occurs in nearly 70% of patients with metastatic prostate
cancer (PCa), and represents the leading cause of death in patients with PCa. Emerging …

Background Gastric cancer (GC) is a malignant tumour, with high morbidity and mortality
rates worldwide. The occurrence and development of GC is a complex process involving …

Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality
rate among cancer patients. Interestingly, the interaction between the immune system and …

Breast cancer (BC) is the first worldwide most frequent cancer in both sexes and the most
commonly diagnosed in females. Although BC mortality has been thoroughly declining over …