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Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization
While many efforts have been made to pave the way toward human space colonization, little
consideration has been given to the methods of protecting spacefarers against harsh cosmic …
consideration has been given to the methods of protecting spacefarers against harsh cosmic …
Trial Watch: Immunotherapy plus radiation therapy for oncological indications
Malignant cells succumbing to some forms of radiation therapy are particularly immunogenic
and hence can initiate a therapeutically relevant adaptive immune response. This reflects …
and hence can initiate a therapeutically relevant adaptive immune response. This reflects …
[HTML][HTML] Formation of γH2AX and pATM foci in human mesenchymal stem cells exposed to low dose-rate gamma-radiation
S Ulyanenko, M Pustovalova, S Koryakin… - International journal of …, 2019 - mdpi.com
DNA double-strand breaks (DSB) are among the most harmful DNA lesions induced by
ionizing radiation (IR). Although the induction and repair of radiation-induced DSB is well …
ionizing radiation (IR). Although the induction and repair of radiation-induced DSB is well …
[HTML][HTML] A paradigm revolution or just better resolution—will newly emerging superresolution techniques identify chromatin architecture as a key factor in radiation …
M Falk, M Hausmann - Cancers, 2020 - mdpi.com
Simple Summary Radiation-induced double-strand breaks (DSBs) are the most toxic and
most difficult to repair DNA lesions and are very heterogeneous. These characteristics place …
most difficult to repair DNA lesions and are very heterogeneous. These characteristics place …
Dose Rate Effects from the 1950s through to the Era of FLASH
KD Held, AL McNamara, J Daartz… - Radiation …, 2024 - meridian.allenpress.com
Numerous dose rate effects have been described over the past 6–7 decades in the radiation
biology and radiation oncology literature depending on the dose rate range being …
biology and radiation oncology literature depending on the dose rate range being …
Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated …
M Pustovalova, ТA Astrelina, A Grekhova… - Aging (Albany …, 2017 - pmc.ncbi.nlm.nih.gov
Mechanisms underlying the effects of low-dose ionizing radiation (IR) exposure (10-100
mGy) remain unknown. Here we present a comparative study of early (less than 24h) and …
mGy) remain unknown. Here we present a comparative study of early (less than 24h) and …
[HTML][HTML] Ionizing radiation and translation control: A link to radiation hormesis?
Protein synthesis, or mRNA translation, is one of the most energy-consuming functions in
cells. Translation of mRNA into proteins is thus highly regulated by and integrated with …
cells. Translation of mRNA into proteins is thus highly regulated by and integrated with …
[HTML][HTML] Utilization of DNA double-strand breaks for biodosimetry of ionizing radiation exposure
A Bushmanov, N Vorobyeva, D Molodtsova… - Environmental …, 2022 - Elsevier
Abstract Analysis of DNA double-strand breaks (DSBs) is an important novel tool to estimate
the biological effects of ionizing radiation. Despite the large number of developed methods …
the biological effects of ionizing radiation. Despite the large number of developed methods …
γH2AX, 53BP1 and Rad51 protein foci changes in mesenchymal stem cells during prolonged X-ray irradiation
A Tsvetkova, IV Ozerov, M Pustovalova… - …, 2017 - pmc.ncbi.nlm.nih.gov
At high exposure levels ionizing radiation is a carcinogen. Little is known about how human
stem cells, which are known to contribute to tumorigenesis, respond to prolonged radiation …
stem cells, which are known to contribute to tumorigenesis, respond to prolonged radiation …
RAD 54 forms DNA repair foci in response to DNA damage in living plant cells
T Hirakawa, J Hasegawa, CI White… - The Plant …, 2017 - Wiley Online Library
Plants have various defense mechanisms against environmental stresses that induce DNA
damage. Genetic and biochemical analyses have revealed the sensing and signaling of …
damage. Genetic and biochemical analyses have revealed the sensing and signaling of …