Dietary flavonoids, which occur in many plant foods, are considered as the most active
constituents among the plant-derived ones in vitro and in vivo. To date, many studies have …

Objectives: Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen
(RNS) species, along with the failure of balancing effects of endogenous antioxidant …

Hypoglycemic activity‐guided separation of ethanol extracts from the fruits of Cornus
officinalis Sieb. et Zucc (CO) led to the isolation of loganin, morroniside, and ursolic acid …

Long-term exposure to elevated levels of manganese (Mn) causes manganism, a
neurodegenerative disorder with Parkinson's disease (PD)-like symptoms. Increasing …

The most common form of dementia is Alzheimer's disease which is characterized by
memory loss and cognitive disorders. The pathogenesis of Alzheimer's disease is not known …

Background Peripheral nerve injury can produce chronic and ultimately neuropathic pain.
The chronic constriction injury (CCI) model has provided a deeper understanding of …

CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger
receptor class B family and regulates the pathological progress of metabolic diseases. CD36 …

Cisplatin is the most widely used chemotherapeutic agent. However, it often causes
nephrotoxicity, which results in acute kidney injury (AKI). Therefore, we urgently need a drug …

Neurodegenerative disorders (NDs) are heterogeneous groups of ailments typically
characterized by progressive damage of the nervous system. Several drugs are used to treat …

Background Neuropathic pain has been shown to be modulated by the activation of the
chemokine CXC motif ligand 12 (CXCL12)/chemokine CXC receptor 4 (CXCR4) dependent …