Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …

Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

The respective antitumoral and protumoral roles of M1 and M2 tumor-associated
macrophages (TAM) typify the complexity of macrophage function in cancer. In lung cancer …

Tumor cells exist in close proximity with non-malignant cells. Extensive and multilayered
crosstalk between tumor cells and stromal cells tailors the tumor microenvironment (TME) to …

Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal
fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor …

Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for
expansion and relapse after therapy. Here we report on quantitative analyses of lineage …