Growing cancer incidence and mortality worldwide demands development of accurate
biomarkers to perfect detection, diagnosis, prognostication and monitoring. Urologic …

EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes
methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target …

Background STAT3 signaling plays the pivotal role in tumorigenesis through EZH2
epigenetic modification, which enhanced STAT3 activity by increased tyrosine …

The long-term survival of patients with advanced urothelial carcinoma (UCa) is limited
because of innate resistance to treatment. We identified elevated expression of the histone …

micro RNA s (mi RNA s) have been proposed to be key regulators of diverse biological
processes such as transcriptional regulation, cell growth and tumorigenesis. Wnt signaling …

Simple Summary Regulation of gene expression is important for appropriate cell
development but can also lead to inappropriate cell transformation resulting in cancer …

Seminal discoveries have established that epigenetic modifications are important for driving
tumor progression. Polycomb group (PcG) proteins are highly conserved epigenetic …

Bladder cancer is a highly prevalent human disease in which retinoblastoma (Rb) pathway
inactivation and epigenetic alterations are common events. However, the connection …

Prostate, bladder, kidney and testis cancers, the most common genitourinary (GU)
neoplasms, are generally clinically silent at their earliest stages when curative treatment is …

Chromatin biology and epigenetics are scientific fields that are rapid expanding due to their
fundamental role in understanding cell development, heritable characters and progression …