While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …

Obesity as a result of overeating as well as a number of well described eating disorders has
been accurately considered to be a world-wide epidemic. Recently a number of theories …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

In humans, sleep and wakefulness and the associated cognitive processes are regulated
through interactions between sleep homeostasis and the circadian system. Chronic …

Sleep and sleep disorders are complex and highly variable phenotypes regulated by many
genes and environment. The catechol-O-methyltransferase (COMT) gene is an interesting …

Abstract Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation
of catechol substrates, classically in catecholamine metabolism, but also acting upon other …

This review summarizes current research on the genetics of insomnia, as genetic
contributions are thought to be important for insomnia etiology. We begin by providing an …

Objective Adolescence is a critical period for circadian rhythm, with a strong shift toward
eveningness around age 14. Also, eveningness in adolescence has been found to predict …

Background Following the first association between the dopamine D2 receptor gene
polymorphism and severe alcoholism, there has been an explosion of research reports in …

This review summarizes the available data about genetic factors which can link ischemic
stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by …