The evolution of SARS-CoV-2

PV Markov, M Ghafari, M Beer, K Lythgoe… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …

Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

[HTML][HTML] SARS-CoV-2 viral load and shedding kinetics

O Puhach, B Meyer, I Eckerle - Nature Reviews Microbiology, 2023 - nature.com
SARS-CoV-2 viral load and detection of infectious virus in the respiratory tract are the two
key parameters for estimating infectiousness. As shedding of infectious virus is required for …

Viral persistence, reactivation, and mechanisms of long COVID

B Chen, B Julg, S Mohandas, SB Bradfute - Elife, 2023 - elifesciences.org
The COVID-19 global pandemic caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection has infected hundreds of millions of individuals …

Infectious disease in an era of global change

RE Baker, AS Mahmud, IF Miller, M Rajeev… - Nature reviews …, 2022 - nature.com
The twenty-first century has witnessed a wave of severe infectious disease outbreaks, not
least the COVID-19 pandemic, which has had a devastating impact on lives and livelihoods …

Lateral flow test engineering and lessons learned from COVID-19

J Budd, BS Miller, NE Weckman, D Cherkaoui… - Nature Reviews …, 2023 - nature.com
The acceptability and feasibility of large-scale testing with lateral flow tests (LFTs) for clinical
and public health purposes has been demonstrated during the COVID-19 pandemic. LFTs …

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B. 1.617. 2) variant in vaccinated and unvaccinated individuals in the UK: a prospective …

A Singanayagam, S Hakki, J Dunning… - The lancet infectious …, 2022 - thelancet.com
Summary Background The SARS-CoV-2 delta (B. 1.617. 2) variant is highly transmissible
and spreading globally, including in populations with high vaccination rates. We aimed to …

Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond

MD Parkins, BE Lee, N Acosta, M Bautista… - Clinical microbiology …, 2024 - journals.asm.org
Wastewater-based surveillance (WBS) has undergone dramatic advancement in the context
of the coronavirus disease 2019 (COVID-19) pandemic. The power and potential of this …

Prevalence of persistent SARS-CoV-2 in a large community surveillance study

M Ghafari, M Hall, T Golubchik, D Ayoubkhani, T House… - Nature, 2024 - nature.com
Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future
outbreaks,,,–, give rise to highly divergent lineages,–and contribute to cases with post-acute …

The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

C Schultheiß, E Willscher, L Paschold, C Gottschick… - Cell Reports …, 2022 - cell.com
Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …