How to study anxiety and depression in rodent models of chronic pain?
Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …
suffering from chronic pain. Over time, different tests and models have been developed in …
Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide
N Sestakova, A Puzserova, M Kluknavsky… - Interdisciplinary …, 2013 - sciendo.com
In various areas of the bio-medical, pharmacological and psychological research a multitude
of behavioural tests have been used to investigate the effects of environmental, genetic and …
of behavioural tests have been used to investigate the effects of environmental, genetic and …
Measuring anxiety-like behaviors in rodent models of traumatic brain injury
Anxiety is a common complaint following acquired traumatic brain injury (TBI). However, the
measurement of dysfunctional anxiety behavioral states following experimental TBI in …
measurement of dysfunctional anxiety behavioral states following experimental TBI in …
Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague–Dawley rats: effects of anxiolytic and anxiogenic agents
AA Braun, MR Skelton, CV Vorhees… - Pharmacology …, 2011 - Elsevier
The elevated plus and zero mazes (Plus and Zero, respectively) are used to assess
behavior related to anxiety in rodents but direct comparisons of the two tests are lacking for …
behavior related to anxiety in rodents but direct comparisons of the two tests are lacking for …
Animal models of anxiety: a comprehensive review
Animal models can be used to contribute to understanding the information about molecular
mechanisms involved in anxiety and for screening and develo** new medications for their …
mechanisms involved in anxiety and for screening and develo** new medications for their …
Soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice
NA Hawkins, M Jurado, TT Thaxton, SE Duarte… - …, 2021 - Wiley Online Library
Objective Dravet syndrome is a severe developmental and epileptic encephalopathy (DEE)
most often caused by de novo pathogenic variants in SCN1A. Individuals with Dravet …
most often caused by de novo pathogenic variants in SCN1A. Individuals with Dravet …
Pathogenic infection in male mice changes sperm small RNA profiles and transgenerationally alters offspring behavior
Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon
changes in experience and environment. Immune activation due to infection can also …
changes in experience and environment. Immune activation due to infection can also …
Global cerebral ischemia: synaptic and cognitive dysfunction
J T. Neumann, C H. Cohan, K R. Dave… - Current drug …, 2013 - benthamdirect.com
Cardiopulmonary arrest is one of the leading causes of death and disability, primarily
occurring in the aged population. Numerous global cerebral ischemia animal models induce …
occurring in the aged population. Numerous global cerebral ischemia animal models induce …
Social isolation after stroke leads to depressive-like behavior and decreased BDNF levels in mice
LM O'Keefe, SJ Doran, L Mwilambwe-Tshilobo… - Behavioural brain …, 2014 - Elsevier
Social isolation prior to stroke leads to poorer outcomes after an ischemic injury in both
animal and human studies. However, the impact of social isolation following stroke, which …
animal and human studies. However, the impact of social isolation following stroke, which …
Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions
Parkinson's disease (PD) is defined by motor symptoms such as tremor at rest, bradykinesia,
postural instability, and stiffness. In addition to the classical motor defects that define PD, up …
postural instability, and stiffness. In addition to the classical motor defects that define PD, up …