Consensus on diagnosis and management of Cushing's disease: a guideline update
Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term
management to optimise patient outcomes. The Pituitary Society convened a consensus …
management to optimise patient outcomes. The Pituitary Society convened a consensus …
Complications of Cushing's syndrome: state of the art
Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and
excessive secretion of cortisol. The syndrome is associated with increased mortality and …
excessive secretion of cortisol. The syndrome is associated with increased mortality and …
Efficacy and safety of osilodrostat in patients with Cushing's disease (LINC 3): a multicentre phase III study with a double-blind, randomised withdrawal phase
Background Cushing's disease is a rare endocrine disorder characterised by cortisol
overproduction with severe complications. Therapies for cortisol reduction are often …
overproduction with severe complications. Therapies for cortisol reduction are often …
The treatment of Cushing's disease
R Pivonello, M De Leo, A Cozzolino… - Endocrine …, 2015 - academic.oup.com
Abstract Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe
endocrine disease caused by a corticotroph pituitary tumor and associated with increased …
endocrine disease caused by a corticotroph pituitary tumor and associated with increased …
Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification
OBJECT An important prognostic factor for the surgical outcome and recurrence of a pituitary
adenoma is its invasiveness into parasellar tissue, particularly into the space of the …
adenoma is its invasiveness into parasellar tissue, particularly into the space of the …
Cushing's syndrome
Chronic exposure to excess glucorticoids results in diverse manifestations of Cushing's
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …
International Union of Basic and Clinical Pharmacology. CV. Somatostatin receptors: structure, function, ligands, and new nomenclature
T Günther, G Tulipano, P Dournaud, C Bousquet… - Pharmacological …, 2018 - Elsevier
Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …
Recurrent gain-of-function USP8 mutations in Cushing's disease
Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary
adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of …
adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of …
[HTML][HTML] A 12-month phase 3 study of pasireotide in Cushing's disease
Background Cushing's disease is associated with high morbidity and mortality. Pasireotide,
a potential therapy, has a unique, broad somatostatin-receptor–binding profile, with high …
a potential therapy, has a unique, broad somatostatin-receptor–binding profile, with high …
Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome
M Fleseriu, BMK Biller, JW Findling… - The Journal of …, 2012 - academic.oup.com
Context: Cushing's syndrome (CS) is a disorder associated with significant morbidity and
mortality due to prolonged exposure to high cortisol concentrations. Objective: Our objective …
mortality due to prolonged exposure to high cortisol concentrations. Objective: Our objective …