The exocyst is an octameric protein complex that is implicated in the tethering of secretory
vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal …

A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

All cell types polarize, at least transiently, during division or to generate specialized shapes
and functions. This capacity extends from yeast to mammals, and it is now clear that many …

The exocyst complex is an evolutionarily conserved multisubunit protein complex implicated
in tethering secretory vesicles to the plasma membrane. Originally identified two decades …

Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for
generating cell diversity during development. The budding yeast Saccharomyces cerevisiae …

Members of the Rab or ARF/Sar branches of the Ras GTPase superfamily regulate almost
every step of intracellular membrane traffic. A rapidly growing body of evidence indicates …

At steady state, most Rho GTPases are bound in the cytosol to Rho guanine nucleotide
dissociation inhibitors (RhoGDIs). RhoGDIs have generally been considered to hold Rho …

The exocyst is an octameric protein complex, which mediates the tethering of post-Golgi
secretory vesicles to the plasma membrane before exocytic fusion. The exocyst assembles …

Protein secretion is an essential process for living organisms. In eukaryotes, this
encompasses numerous steps mediated by several hundred cellular proteins. The core …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …