Development of cross-species translational paradigms for psychiatric research in the Research Domain Criteria era
JW Young - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
The past 30 years of IBNS has included research attempting to treat the cognitive and
behavioral deficits observed in people with psychiatric conditions. Early work utilized drugs …
behavioral deficits observed in people with psychiatric conditions. Early work utilized drugs …
Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease
Translating results from pre-clinical animal studies to successful human clinical trials in
neurodegenerative and neuropsychiatric disease presents a significant challenge. While …
neurodegenerative and neuropsychiatric disease presents a significant challenge. While …
Age-related dysregulation of homeostatic control in neuronal microcircuits
CI Radulescu, N Doostdar, N Zabouri… - Nature …, 2023 - nature.com
Neuronal homeostasis prevents hyperactivity and hypoactivity. Age-related hyperactivity
suggests homeostasis may be dysregulated in later life. However, plasticity mechanisms …
suggests homeostasis may be dysregulated in later life. However, plasticity mechanisms …
Developmental origin of oligodendrocytes determines their function in the adult brain
S Foerster, EM Floriddia, D van Bruggen… - Nature …, 2024 - nature.com
In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell
populations and their progeny, oligodendrocytes, emerge from three distinct regions in a …
populations and their progeny, oligodendrocytes, emerge from three distinct regions in a …
Electrophysiological correlates of attention in the locus coeruleus–prelimbic cortex circuit during the rodent continuous performance test
Sustained attention, the ability to focus on an activity or stimulus over time, is significantly
impaired in many psychiatric disorders, and there remains a major unmet need in treating …
impaired in many psychiatric disorders, and there remains a major unmet need in treating …
New frontiers in translational research: Touchscreens, open science, and the mouse translational research accelerator platform
Many neurodegenerative and neuropsychiatric diseases and other brain disorders are
accompanied by impairments in high‐level cognitive functions including memory, attention …
accompanied by impairments in high‐level cognitive functions including memory, attention …
Animal behavior in psychedelic research
AU Odland, JL Kristensen, JT Andreasen… - Pharmacological …, 2022 - Elsevier
Psychedelic-assisted psychotherapy holds great promise in the treatment of mental health
disorders. Research into 5-hydroxytryptamine 2A receptor (5-HT 2A R) agonist psychedelic …
disorders. Research into 5-hydroxytryptamine 2A receptor (5-HT 2A R) agonist psychedelic …
[HTML][HTML] The translational genetics of ADHD and related phenotypes in model organisms
J Cabana-Domínguez, E Antón-Galindo… - … & biobehavioral reviews, 2023 - Elsevier
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental
disorder resulting from the interaction between genetic and environmental risk factors. It is …
disorder resulting from the interaction between genetic and environmental risk factors. It is …
Chronic interleukin-1β in the dorsal hippocampus impairs behavioural pattern separation
Understanding the long-term consequences of chronic inflammation in the hippocampus
may help to develop therapeutic targets for the treatment of cognitive disorders related to …
may help to develop therapeutic targets for the treatment of cognitive disorders related to …
Assessing impulsivity in humans and rodents: taking the translational road
Impulsivity is a multidimensional construct encompassing domains of behavioral inhibition
as well as of decision making. It is often adaptive and associated with fast responses, being …
as well as of decision making. It is often adaptive and associated with fast responses, being …