The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

The human cortex comprises diverse cell types that emerge from an initially uniform
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …

Salamanders are tetrapod models to study brain organization and regeneration; however,
the identity and evolutionary conservation of brain cell types are largely unknown. We …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

A wealth of specialized neuroendocrine command systems intercalated within the
hypothalamus control the most fundamental physiological needs in vertebrates …

The cerebral cortex is at the core of brain functions that are thought to be particularly
developed in the human species. Human cortex specificities stem from divergent features of …

Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

The neocortex varies in size and complexity among mammals due to the tremendous
variability in the number and diversity of neuronal subtypes across species. The increased …