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Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …
[HTML][HTML] The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics
Multiple sclerosis is a neuroinflammatory and neurodegenerative disorder of the central
nervous system that can be considered a network disorder. In MS, lesional pathology …
nervous system that can be considered a network disorder. In MS, lesional pathology …
Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study
Cognitive decline is common in multiple sclerosis and strongly affects overall quality of life.
Despite the identification of cross-sectional MRI correlates of cognitive impairment …
Despite the identification of cross-sectional MRI correlates of cognitive impairment …
Mind the gap: from neurons to networks to outcomes in multiple sclerosis
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …
networks, particularly in health and in classical neurodegenerative conditions such as …
[HTML][HTML] Task-and resting-state fMRI studies in multiple sclerosis: From regions to systems and time-varying analysis. Current status and future perspective
Multiple sclerosis (MS) is a neurological disorder affecting the central nervous system and
features extensive functional brain changes that are poorly understood but relate strongly to …
features extensive functional brain changes that are poorly understood but relate strongly to …
The prevalence of cognitive impairment in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis
It is increasingly recognized that cognitive symptoms are a common sequelae of relapsing-
remitting multiple sclerosis and are associated with adverse functional consequences …
remitting multiple sclerosis and are associated with adverse functional consequences …
Higher‐order functional connectivity analysis of resting‐state functional magnetic resonance imaging data using multivariate cumulants
Blood‐level oxygenation‐dependent (BOLD) functional magnetic resonance imaging (fMRI)
is the most common modality to study functional connectivity in the human brain. Most …
is the most common modality to study functional connectivity in the human brain. Most …
Cortical atrophy accelerates as cognitive decline worsens in multiple sclerosis
Objective To determine which pathologic process could be responsible for the acceleration
of cognitive decline during the course of multiple sclerosis (MS), using longitudinal structural …
of cognitive decline during the course of multiple sclerosis (MS), using longitudinal structural …
Long-range connections are more severely damaged and relevant for cognition in multiple sclerosis
An efficient network such as the human brain features a combination of global integration of
information, driven by long-range connections, and local processing involving short-range …
information, driven by long-range connections, and local processing involving short-range …
Hub overload and failure as a final common pathway in neurological brain network disorders
Understanding the concept of network hubs and their role in brain disease is now rapidly
becoming important for clinical neurology. Hub nodes in brain networks are areas highly …
becoming important for clinical neurology. Hub nodes in brain networks are areas highly …