Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Poor aqueous solubility of both, existing drug molecules and those which are currently in the
developmental stage, have posed a great challenge to pharmaceutical scientists because …

Industrial-scale pharmaceutical applications still face many challenges in overcoming the
low absorption and bioavailability of poorly water-soluble drugs. Hot-melt extrusion has …

Amorphous solid dispersions (ASDs) utilize the kinetic stability of the amorphous state to
stabilize drug molecules within a glassy polymer matrix. Therefore, understanding the glassy …

Purpose The purpose of this work is to evaluate the interrelationship of microstructure,
properties, and dissolution performance for amorphous solid dispersions (ASDs) prepared …

This study focused on improving the physicochemical characteristics of aprepitant with poor
water solubility by preparing solid dispersion (SD). To prepare the SD with HPMCAS-LF, the …

Low water solubility is the main hindrance in the growth of pharmaceutical industry.
Approximately 90% of newer molecules under investigation for drugs and 40% of novel …

Understanding drug solubility in various solvents is of great importance to the
pharmaceutical industry for design of the process. To date, various modeling approaches …

Co-processing of APIs, the practice of creating multi-component APIs directly in chemical
processing facilities used to make drug substance, is gaining increased attention with a view …

Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs),
notable for its ability to enable the production of ASDs containing pharmaceuticals with …