BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

Medical treatments for cancers or other conditions can lead to permanent infertility. Infertility
is an insidious disease that impacts not only the ability to have a biological child but also the …

The spermatozoon is a highly differentiated and polarized cell, with two main structures: the
head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum …

Organisms with targeted genomic modifications are efficiently produced by gene editing in
embryos using CRISPR/Cas9 RNA-guided DNA endonuclease. Here, to facilitate germline …

Background The testis is specific in that it produces haploid germ cells of which
autoantigens newly appear long after the neonatal immune tolerance. Under normal …

The ability to spur growth of early stage gametic cells recovered from neonates could lead to
significant advances in rescuing the genomes of rare genotypes or endangered species that …

In a develo** human corpus luteum, a closely regulated cellular communication system
exists between the luteal steroidogenic cells and endothelial cells. This system guaranties …

Spermatogonial stem cells (SSCs) are a rare group of cells in the testis that undergo self-
renewal and complex sequences of differentiation to initiate and sustain spermatogenesis …

Contents Assisted reproductive technology (ART) has great potential for conservation, but its
successful application in captive breeding programmes of endangered species is often …

Sperm cryopreservation is the most common procedure used to establish germplasm banks
for endangered species-but sometimes sperm cells cannot be obtained. In such cases …