Landscape of next-generation sequencing technologies

TP Niedringhaus, D Milanova, MB Kerby… - Analytical …, 2011 - ACS Publications
DNA sequencing is in the throes of an enormous technolog-ical shift marked by dramatic
throughput increases, a precipitously drop** per-base cost of raw sequence, and an …

Lighting up the force: investigating mechanisms of mechanotransduction using fluorescent tension probes

C Jurchenko, KS Salaita - Molecular and cellular biology, 2015 - Am Soc Microbiol
The ability of cells to sense the physical nature of their surroundings is critical to the survival
of multicellular organisms. Cellular response to physical cues from adjacent cells and the …

Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors

M Wanunu, T Dadosh, V Ray, J **… - Nature …, 2010 - nature.com
Small RNA molecules have an important role in gene regulation and RNA silencing therapy,
but it is challenging to detect these molecules without the use of time-consuming radioactive …

Solid-state nanopore fabrication by automated controlled breakdown

M Waugh, K Briggs, D Gunn, M Gibeault, S King… - Nature …, 2020 - nature.com
Solid-state nanopores are now well established as single-biomolecule sensors that hold
great promise as sensing elements in diagnostic and sequencing applications. However …

Slow DNA transport through nanopores in hafnium oxide membranes

J Larkin, R Henley, DC Bell, T Cohen-Karni… - ACS …, 2013 - ACS Publications
We present a study of double-and single-stranded DNA transport through nanopores
fabricated in ultrathin (2–7 nm thick) freestanding hafnium oxide (HfO2) membranes. The …

Plasmonic nanopores for trap**, controlling displacement, and sequencing of DNA

M Belkin, SH Chao, MP Jonsson, C Dekker… - ACS …, 2015 - ACS Publications
With the aim of develo** a DNA sequencing methodology, we theoretically examine the
feasibility of using nanoplasmonics to control the translocation of a DNA molecule through a …

Measuring the electric charge and zeta potential of nanometer-sized objects using pyramidal-shaped nanopores

N Arjmandi, W Van Roy, L Lagae, G Borghs - Analytical chemistry, 2012 - ACS Publications
Nanometer-scale pores are capable of detecting the size and concentration of nanometer-
sized analytes at low concentrations upon analyzing their translocation through the pore, in …

Direct sensing of cancer biomarkers in clinical samples with a designed nanopore

Y Lin, YL Ying, X Shi, SC Liu, YT Long - Chemical Communications, 2017 - pubs.rsc.org
Here, we show a designed solid-state nanopore sensor for the direct sensing and
quantification of prostate-specific antigen (PSA) as cancer biomarker in serum without any …

Mechanical trap** of DNA in a double-nanopore system

S Pud, SH Chao, M Belkin, D Verschueren… - Nano …, 2016 - ACS Publications
Nanopores have become ubiquitous components of systems for single-molecule
manipulation and detection, in particular DNA sequencing where electric field driven …

Single-molecule observation of protein adsorption onto an inorganic surface

DJ Niedzwiecki, J Grazul… - Journal of the American …, 2010 - ACS Publications
Understanding the interactions between silicon-based materials and proteins from the
bloodstream is of key importance in a myriad of realms, such as the design of nanofluidic …