Family portraits: the enzymes behind benzylisoquinoline alkaloid diversity
Benzylisoquinoline alkaloids (BIAs) are a group of specialized metabolites found
predominantly in the plant order Ranunculales. Approximately 2500 naturally occurring BIAs …
predominantly in the plant order Ranunculales. Approximately 2500 naturally occurring BIAs …
Human carbonyl reductases
P Malátková, E Maser, V Wsól - Current drug metabolism, 2010 - ingentaconnect.com
Enzymatic carbonyl reduction means the formation of a hydroxy function out of a ketone or
aldehyde moiety and applies for the metabolism of physiological (endogenous) or …
aldehyde moiety and applies for the metabolism of physiological (endogenous) or …
Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver
KC Wu, JY Cui, CD Klaassen - PloS one, 2012 - journals.plos.org
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery
of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH …
of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH …
Carbonyl reduction pathways in drug metabolism
P Malátková, V Wsól - Drug metabolism reviews, 2014 - Taylor & Francis
The understanding of drug biotransformation is an important medical topic. The oxidative
pathways that involve CYPs have been extensively studied in drug metabolism in contrast to …
pathways that involve CYPs have been extensively studied in drug metabolism in contrast to …
Redesigning alcohol dehydrogenases/reductases for more efficient biosynthesis of enantiopure isomers
Alcohol dehydrogenases/reductases predominantly catalyze the asymmetric biosynthesis of
optically pure stereoisomers because of their unique chiral constitutions. The …
optically pure stereoisomers because of their unique chiral constitutions. The …
Environmentally robust rhodamine reporters for probe-based cellular detection of the cancer-linked oxidoreductase hNQO1
QA Best, AE Johnson, B Prasai, A Rouillere… - ACS Chemical …, 2016 - ACS Publications
We successfully synthesized a fluorescent probe capable of detecting the cancer-associated
NAD (P) H: quinoneoxidoreductase isozyme-1 within human cells, based on results from an …
NAD (P) H: quinoneoxidoreductase isozyme-1 within human cells, based on results from an …
Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells–the involvement of carbonyl reductase 1 inhibition
One of the causes of therapeutic failure of chemotherapy is cancer cell resistance. In the
case of anthracyclines, many resistance mechanisms have been described. One of them …
case of anthracyclines, many resistance mechanisms have been described. One of them …
Characterisation of the metabolites of 1, 8-cineole transferred into human milk: Concentrations and ratio of enantiomers
F Kirsch, A Buettner - Metabolites, 2013 - mdpi.com
1, 8-Cineole is a widely distributed odorant that also shows physiological effects, but whose
human metabolism has hitherto not been extensively investigated. The aim of the present …
human metabolism has hitherto not been extensively investigated. The aim of the present …
The role of carbonyl reductase 1 in drug discovery and development
SM Shi, L Di - Expert Opinion on Drug Metabolism & Toxicology, 2017 - Taylor & Francis
ABSTRACT Introduction: Carbonyl reductase 1 (CBR1) plays a critical role in drug
metabolism of ketones and aldehydes. CBR1 has broad substrate specificity and is involved …
metabolism of ketones and aldehydes. CBR1 has broad substrate specificity and is involved …
Virtual screening applications in short-chain dehydrogenase/reductase research
Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play
fundamental roles in adrenal and gonadal steroidogenesis as well as in the metabolism of …
fundamental roles in adrenal and gonadal steroidogenesis as well as in the metabolism of …