[HTML][HTML] The nicotinamide/streptozotocin rodent model of type 2 diabetes: renal pathophysiology and redox imbalance features

LJ Yan - Biomolecules, 2022 - mdpi.com
Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has
been a great advance in our understanding of the pathogenesis of DN, no effective …

Anthocyanins and vascular health: a matter of metabolites

J Festa, A Hussain, Z Al-Hareth, H Singh, M Da Boit - Foods, 2023 - mdpi.com
Anthocyanins are a subgroup of flavonoid polyphenols previously investigated for improving
cardiovascular health and preventing the development of endothelial dysfunction. However …

[HTML][HTML] Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis

J Ni, L Zhang, G Feng, W Bao, Y Wang, Y Huang… - Pharmacological …, 2024 - Elsevier
The damage of integrated epithelial epithelium is a key pathogenic factor and closely
associated with the recurrence of ulcerative colitis (UC). Here, we reported that vanillic acid …

Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients

LA Dahabiyeh, RM Nimer, KM Sumaily… - Scientific Reports, 2023 - nature.com
Chronic kidney disease (CKD) is a serious public health problem characterized by
progressive kidney function loss leading to end-stage renal disease (ESRD) that demands …

Phytochemical profiling, toxicity studies, wound healing, analgesic and anti-inflammatory activities of Musa paradisiaca L. Musaceae (Plantain) stem extract in rats

CN Ekweogu, EI Akubugwo, O Emmanuel… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The stem of Musa paradisiaca (plantain) has found
application in traditional medicine for the treatment of diabetes, inflammation, ulcers and …

Emerging roles and therapeutic applications of Arachidonic Acid pathways in Cardiometabolic diseases

Y Hu, W Li, X Cheng, H Yang, ZG She, J Cai… - Circulation …, 2024 - ahajournals.org
Cardiometabolic disease has become a major health burden worldwide, with sharply
increasing prevalence but highly limited therapeutic interventions. Emerging evidence has …

Underlying mechanisms behind the neuroprotective effect of vanillic acid against diabetes‐associated cognitive decline: An in vivo study in a rat model

S Ghaderi, P Gholipour, A Komaki… - Phytotherapy …, 2024 - Wiley Online Library
Hippocampal synaptic dysfunction, oxidative stress, neuroinflammation, and neuronal loss
play critical roles in the pathophysiology of diabetes‐associated cognitive decline (DACD) …

[HTML][HTML] Ameliorative effect of vanillic acid against scopolamine-induced learning and memory impairment in rat via attenuation of oxidative stress and dysfunctional …

GY Choi, IS Lee, E Moon, H Choi, AR Je… - Biomedicine & …, 2024 - Elsevier
Alzheimer's disease (AD) is characterized by cognitive impairment, loss of learning and
memory, and abnormal behaviors. Scopolamine (SCOP) is a non-selective antagonist of …

Gentisic acid protects against diabetic nephropathy in Nicotinamide-Streptozotocin administered male mice by attenuating oxidative stress and inflammation: The role …

RN Razliqi, A Ahangarpour, SA Mard… - Chemico-Biological …, 2023 - Elsevier
Oxidative stress and inflammation play a pivotal role in the pathogenesis of diabetic
nephropathy (DN). Local renin-angiotensin systems (RAS) contribute to the pathogenesis …