The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers
Z Sondka, S Bamford, CG Cole, SA Ward… - Nature Reviews …, 2018 - nature.com
Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …
WHO 2016 Classification of gliomas
P Wesseling, D Capper - Neuropathology and applied …, 2018 - Wiley Online Library
Gliomas are the most frequent intrinsic tumours of the central nervous system and
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …
Integrated molecular and clinical analysis of 1,000 pediatric low-grade gliomas
Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
Advances in the molecular genetics of gliomas—implications for classification and therapy
Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …
alterations and epigenetic profiles associated with different types of gliomas. These …
The 2021 WHO classification of tumors of the central nervous system: an update on pediatric low‐grade gliomas and glioneuronal tumors
TA Bale, MK Rosenblum - Brain Pathology, 2022 - Wiley Online Library
The 2021 5th edition of the WHO Classification of Tumors of the Central Nervous System
reflects the discovery of genetic alterations underlying many central nervous system (CNS) …
reflects the discovery of genetic alterations underlying many central nervous system (CNS) …
Pediatric low-grade glioma in the era of molecular diagnostics
Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …
spectrum of histologic entities which are currently assigned World Health Organisation …
Alternative‐splicing defects in cancer: splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
LM Urbanski, N Leclair… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …
MYB oncoproteins: emerging players and potential therapeutic targets in human cancer
Y Cicirò, A Sala - Oncogenesis, 2021 - nature.com
MYB transcription factors are highly conserved from plants to vertebrates, indicating that
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …
cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAFV600E mutation
Diffuse gliomas occur at all ages, but their incidence is highest among older adults [7]. They
have astrocytic or oligodendroglial morphologies and are represented across WHO grades II …
have astrocytic or oligodendroglial morphologies and are represented across WHO grades II …
Pediatric gliomas: current concepts on diagnosis, biology, and clinical management
Gliomas are the most common CNS tumors in children and adolescents, and they show an
extremely broad range of clinical behavior. The majority of pediatric gliomas present as …
extremely broad range of clinical behavior. The majority of pediatric gliomas present as …