Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors
RA DeFronzo, WB Reeves, AS Awad - Nature Reviews Nephrology, 2021 - nature.com
Diabetic kidney disease is the leading cause of kidney failure worldwide; in the USA, it
accounts for over 50% of individuals entering dialysis or transplant programmes. Unlike …
accounts for over 50% of individuals entering dialysis or transplant programmes. Unlike …
Signaling pathways of chronic kidney diseases, implications for therapeutics
Q Yuan, B Tang, C Zhang - Signal transduction and targeted therapy, 2022 - nature.com
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …
Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function
Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …
High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction
Y Sun, X Ge, X Li, J He, X Wei, J Du, J Sun, X Li… - Cell death & …, 2020 - nature.com
Obesity has been recognized as a major risk factor for chronic kidney disease, but the
underlying mechanism remains elusive. Here, we investigated the mechanism whereby long …
underlying mechanism remains elusive. Here, we investigated the mechanism whereby long …
Obesity and kidney disease: hidden consequences of the epidemic
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow
by 40% in the next decade. This increasing prevalence has implications for the risk of …
by 40% in the next decade. This increasing prevalence has implications for the risk of …
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
The prevalence of obesity-related glomerulopathy is increasing in parallel with the
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …
worldwide obesity epidemic. Glomerular hypertrophy and adaptive focal segmental …
Lipid accumulation and chronic kidney disease
Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic
kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is …
kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is …
Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease
Chronic kidney disease (CKD) is a common comorbidity in patients with type 2 diabetes
mellitus (T2DM) and both conditions are increasing in prevalence. CKD is estimated to …
mellitus (T2DM) and both conditions are increasing in prevalence. CKD is estimated to …
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization
Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but
detectable expression of adiponectin can be observed in cell types beyond adipocytes …
detectable expression of adiponectin can be observed in cell types beyond adipocytes …
The impact of insulin resistance on the kidney and vasculature
F Artunc, E Schleicher, C Weigert, A Fritsche… - Nature Reviews …, 2016 - nature.com
Insulin resistance is a systemic disorder that affects many organs and insulin-regulated
pathways. The disorder is characterized by a reduced action of insulin despite increased …
pathways. The disorder is characterized by a reduced action of insulin despite increased …