The past decade has seen significant advances in our understanding of the cell signaling
pathways that drive melanoma in humans. These studies have demonstrated that the …

Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients
eventually relapse with acquired resistance, and others present intrinsic resistance to these …

Using a modified norbornene (methyl bicyclo [2.2. 1] hept-2-ene-2-carboxylate) as a
transient mediator, meta-C–H amination and meta-C–H alkynylation of aniline and phenol …

Shorter reaction times, higher product yields, and enhanced selectivity are some of the
advantages microwave heating has over conventional methods, causing its use to transition …

Protein kinases represent an attractive target in oncology drug discovery. Most of kinase
inhibitors are ATP-competitive and are called type I inhibitors. The ATP-binding pocket is …

Recent years have witnessed palladium-catalyzed C–H activation emerging as a versatile
strategy for the construction of valuable scaffolds. Palladacyclopentane-type intermediates …

Protein kinases are key regulators of cellular signaling and play a critical role in
oncogenesis. Inhibitors of protein kinases are pursued by both industry and academia as a …

To target the multi-facets of Alzheimer's disease (AD), a series of novel GSK-3β inhibitors
containing the 2, 3-diaminopyridine moiety were designed and synthesized. The amide …

V600EB-RAF kinase is the most frequent onco-genic protein kinase mutation in melanoma
and is a promising target to treat malignant melanoma. In this work, a molecular modeling …