Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …
[HTML][HTML] Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment
J Li, DJ Burgess - Acta Pharmaceutica Sinica B, 2020 - Elsevier
The complex tumor microenvironment is a most important factor in cancer development. The
biological microenvironment is composed of a variety of barriers including the extracellular …
biological microenvironment is composed of a variety of barriers including the extracellular …
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
S Meulewaeter, G Nuytten, MHY Cheng… - Journal of Controlled …, 2023 - Elsevier
Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during
the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines …
the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines …
Polymer–lipid hybrid materials
Hierarchic self-assembly underpins much of the form and function seen in synthetic or
biological soft materials. Lipids are paramount examples, building themselves in nature or …
biological soft materials. Lipids are paramount examples, building themselves in nature or …
Liposomes under shear: structure, dynamics, and drug delivery applications
The targeted delivery to specific locations while not causing damage to healthy tissues
efficiently remains a challenge in drug delivery systems. Through addressing this issue …
efficiently remains a challenge in drug delivery systems. Through addressing this issue …
How do surface properties of nanoparticles influence their diffusion in the extracellular matrix? A model study in Matrigel using polymer-grafted nanoparticles
Diffusion of nanomedicines inside the extracellular matrix (ECM) has been identified as a
key factor to achieve homogeneous distribution and therefore therapeutic efficacy. Here, we …
key factor to achieve homogeneous distribution and therefore therapeutic efficacy. Here, we …
Elucidating Structural Configuration of Lipid Assemblies for mRNA Delivery Systems
The development of mRNA delivery systems utilizing lipid-based assemblies holds immense
potential for precise control of gene expression and targeted therapeutic interventions …
potential for precise control of gene expression and targeted therapeutic interventions …
Surfactant assisted rapid-release liposomal strategies enhance the antitumor efficiency of bufalin derivative and reduce cardiotoxicity
L Gao, L Zhang, F He, J Chen, M Zhao… - International Journal …, 2021 - Taylor & Francis
Background BF211, a derivative of bufalin (BF), shows significantly improved solubility and
potent antitumor efficiency compared to BF. Unfortunately, the unwanted toxicity such as …
potent antitumor efficiency compared to BF. Unfortunately, the unwanted toxicity such as …
Therapeutic lipid-coated hybrid nanoparticles against bacterial infections
L Jiang, HW Lee, SCJ Loo - RSC advances, 2020 - pubs.rsc.org
One of the most important health concerns in society is the development of pathogen-
causing nosocomial infections. Since the first discovery of antibiotics, bacterial infections …
causing nosocomial infections. Since the first discovery of antibiotics, bacterial infections …
[HTML][HTML] Small-angle X-ray and neutron scattering applied to lipid-based nanoparticles: Recent advancements across different length scales
Abstract Lipid-based nanoparticles (LNPs), ranging from nanovesicles to non-lamellar
assemblies, have gained significant attention in recent years, as versatile carriers for …
assemblies, have gained significant attention in recent years, as versatile carriers for …