Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well
established for the treatment of malaria, including highly drug-resistant strains. Their efficacy …

Malaria has been a global epidemic health threat since ancient times. It still claims roughly
half a million lives every year in this century. Artemisinin and its derivatives, are frontline …

Artemisinins have become essential antimalarial drugs for increasingly widespread drug-
resistant malaria strains. Although tremendous efforts have been devoted to decipher how …

Artemisinins are efficacious antimalarial drugs widely employed as first-line treatment in
endemic countries under the form of combined therapies. Different molecular modes of …

With the advent of artemisinin resistance, it is timely to revisit the biological basis for the
controversial suggestion that this class of antimalarial exerts its activity by inhibiting a …

Despite efforts to reduce malaria morbidity and mortality, drug-resistant parasites continue to
evade control strategies. Recently, emphasis has shifted away from control and toward …

The disease malaria, caused by the parasite Plasmodium falciparum, remains one of the
most important causes of morbidity and mortality in sub-Saharan Africa. In the absence of an …

Abstract Background The Plasmodium falciparum multidrug resistance 1 (PfMDR1), P.
falciparum Ca 2+-ATPase (PfATP6) and Kelch-13 propeller domain (PfK13) loci are …

The antimalarial drugs artemisinins have been described as inhibiting Ca 2+-ATPase
activity of PfATP6 (Plasmodium falciparum ATP6) after expression in Xenopus oocytes …