The neurobiology of irritable bowel syndrome

EA Mayer, HJ Ryu, RR Bhatt - Molecular psychiatry, 2023 - nature.com
Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that
affects between 5 and 10% of the general population worldwide. The current symptom …

Towards a systems view of IBS

EA Mayer, JS Labus, K Tillisch, SW Cole… - Nature Reviews …, 2015 - nature.com
Despite an extensive body of reported information about peripheral and central mechanisms
involved in the pathophysiology of IBS symptoms, no comprehensive disease model has …

[HTML][HTML] Gender-related differences in irritable bowel syndrome: potential mechanisms of sex hormones

M Meleine, J Matricon - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
According to epidemiological studies, twice as many women as men are affected by irritable
bowel syndrome (IBS) in western countries, suggesting a role for sex hormones in IBS …

Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report

EA Mayer, J Labus, Q Aziz, I Tracey, L Kilpatrick… - Gut, 2019 - gut.bmj.com
Imaging of the living human brain is a powerful tool to probe the interactions between brain,
gut and microbiome in health and in disorders of brain–gut interactions, in particular IBS …

[HTML][HTML] Epidemiology of functional gastrointestinal disorders in Japan and in the world

T Oshima, H Miwa - Journal of neurogastroenterology and motility, 2015 - ncbi.nlm.nih.gov
Functional gastrointestinal disorders (FGIDs), represented by functional dyspepsia (FD) and
irritable bowel syndrome (IBS), are a group of disorders that include variable combinations …

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies

M Camilleri, A Zhernakova, I Bozzarelli… - Nature Reviews …, 2022 - nature.com
The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably
involves genetic predisposition and the effect of environmental factors. Unlike other …

Evidence-based clinical practice guidelines for irritable bowel syndrome

S Fukudo, H Kaneko, H Akiho, M Inamori… - Journal of …, 2015 - Springer
New strategies for the care of irritable bowel syndrome (IBS) are develo** and several
novel treatments have been globally produced. New methods of care should be customized …

5-HT3 receptor antagonists in neurologic and neuropsychiatric disorders: the iceberg still lies beneath the surface

G Fakhfouri, R Rahimian, J Dyhrfjeld-Johnsen… - Pharmacological …, 2019 - Elsevier
HT 3 receptor antagonists, first introduced to the market in the mid-1980s, are proven
efficient agents to counteract chemotherapy-induced emesis. Nonetheless, recent …

Imaging brain mechanisms in chronic visceral pain

EA Mayer, A Gupta, LA Kilpatrick, JY Hong - Pain, 2015 - journals.lww.com
Chronic visceral pain syndromes are important clinical problems with largely unmet medical
needs. Based on the common overlap with other chronic disorders of visceral or somatic …

Serotonergic innervation of the amygdala: targets, receptors, and implications for stress and anxiety

E Asan, M Steinke, KP Lesch - Histochemistry and cell biology, 2013 - Springer
The amygdala is a core component of neural circuits that mediate processing of emotional,
particularly anxiety and fear-related stimuli across species. In addition, the nuclear complex …