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Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review
Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …
undergoes a series of molecular events that lead to a change in phenotype toward a …
Aortic valve stenosis: from basic mechanisms to novel therapeutic targets
Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …
interventional treatment options have rapidly improved in recent years, symptomatic aortic …
3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels
Heart valve disease is a serious and growing public health problem for which prosthetic
replacement is most commonly indicated. Current prosthetic devices are inadequate for …
replacement is most commonly indicated. Current prosthetic devices are inadequate for …
Mitral valve disease—morphology and mechanisms
Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …
Calcific aortic valve disease: not simply a degenerative process a review and agenda for research from the National Heart and Lung and Blood Institute Aortic …
Calcific aortic valve disease (CAVD) encompasses the range of disease from initial
alterations in the cell biology of the leaflets to end-stage calcification resulting in left …
alterations in the cell biology of the leaflets to end-stage calcification resulting in left …
[HTML][HTML] Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing
different chemokine receptor patterns: CCR2+ CX3CR1+ Ly-6Chi and CCR2–CX3CR1++ …
different chemokine receptor patterns: CCR2+ CX3CR1+ Ly-6Chi and CCR2–CX3CR1++ …
Heart valve structure and function in development and disease
The mature heart valves are made up of highly organized extracellular matrix (ECM) and
valve interstitial cells (VICs) surrounded by an endothelial cell layer. The ECM of the valves …
valve interstitial cells (VICs) surrounded by an endothelial cell layer. The ECM of the valves …
The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology
The study of the cellular and molecular pathogenesis of heart valve disease is an emerging
area of research made possible by the availability of cultures of valve interstitial cells (VICs) …
area of research made possible by the availability of cultures of valve interstitial cells (VICs) …
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
Background—Arterial calcification is associated with cardiovascular events; however,
mechanisms of calcification in atherosclerosis remain obscure. Methods and Results—We …
mechanisms of calcification in atherosclerosis remain obscure. Methods and Results—We …
Heart valve development: regulatory networks in development and disease
In recent years, significant advances have been made in the definition of regulatory
pathways that control normal and abnormal cardiac valve development. Here, we review the …
pathways that control normal and abnormal cardiac valve development. Here, we review the …