DNA-encoded chemical library (DECL) technology is used by the pharmaceutical industry to
discover small molecules capable of modulating biologically relevant targets. DECL …

DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology
platform for the discovery of small-molecule ligands to protein targets of biological and …

DNA-encoded chemical libraries (DELs) have emerged as a powerful technology in drug
discovery. The wide adoption of DELs in the pharmaceutical industry and the rapid …

The development of bioactive small molecules as probes or drug candidates requires
discovery platforms that enable access to chemical diversity and can quickly reveal new …

Membrane proteins on the cell surface perform a myriad of biological functions; however,
ligand discovery for membrane proteins is highly challenging, because a natural cellular …

A DNA-encoded library is a collection of small molecules covalently linked to DNA that has
unique information about the identity and the structure of each library member. A DNA …

The world is totally dependent on medications. As science progresses, new, better, and
cheaper drugs are needed more than ever. The pharmaceutical industry has been …

Terminal deoxynucleotidyl transferase (TdT) is an unusual DNA polymerase that adds
untemplated dNTPs to 3′-ends of DNA. If a target protein is expressed as a TdT fusion and …

DNA‐encoded library (DEL) technologies are transforming the drug discovery process,
enabling the identification of ligands at unprecedented speed and scale. DEL makes use of …

DNA-encoded library (DEL) technology has the potential to dramatically expedite hit
identification in drug discovery owing to its ability to perform protein affinity selection with …