DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …
tumors. However, the radioresistance of cancer cells is still a major limitation for …
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is primarily
found in the elderly population, and several studies have demonstrated that aging is the …
found in the elderly population, and several studies have demonstrated that aging is the …
Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
J Gao, S Peng, X Shan, G Deng, L Shen, J Sun… - Cell death & …, 2019 - nature.com
Radiation-induced lung injury (RILI) is one of the most common and fatal complications of
thoracic radiotherapy, whereas no effective interventions are available. Andrographolide, an …
thoracic radiotherapy, whereas no effective interventions are available. Andrographolide, an …
Discovery of potent and novel dual PARP/BRD4 inhibitors for efficient treatment of pancreatic cancer
SP Wang, Y Li, SH Huang, SQ Wu, LL Gao… - Journal of medicinal …, 2021 - ACS Publications
Targeting poly (ADP-ribose) polymerase1/2 (PARP1/2) is a promising strategy for the
treatment of pancreatic cancer with breast cancer susceptibility gene (BRCA) mutation …
treatment of pancreatic cancer with breast cancer susceptibility gene (BRCA) mutation …
Pyroptosis-induced inflammation and tissue damage
Programmed cell deaths are pathways involving cells playing an active role in their own
destruction. Depending on the signaling system of the process, programmed cell death can …
destruction. Depending on the signaling system of the process, programmed cell death can …
Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway
Idiopathic pulmonary fibrosis (IPF) is a chronic disease with high mortality and is refractory to
treatment. Pulmonary macrophages can both promote and repress fibrosis, however …
treatment. Pulmonary macrophages can both promote and repress fibrosis, however …
BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression
Y Li, Y Wang, W Zhang, X Wang, L Chen, S Wang - Scientific reports, 2021 - nature.com
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors offer a significant clinical benefit
for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. However, the narrow …
for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. However, the narrow …
YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner
C Zhang, L Chen, C **e, F Wang, J Wang… - The EMBO …, 2024 - embopress.org
Accumulation of DNA damage in the lung induces cellular senescence and promotes age-
related diseases such as idiopathic pulmonary fibrosis (IPF). Hence, understanding the …
related diseases such as idiopathic pulmonary fibrosis (IPF). Hence, understanding the …
The multifaceted roles of FOXM1 in pulmonary disease
Y Li, F Wu, Q Tan, M Guo, P Ma, X Wang… - Cell Communication and …, 2019 - Springer
Abstract Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition
and M phase progression in the cell cycle, plays a principal role in many physiological and …
and M phase progression in the cell cycle, plays a principal role in many physiological and …
Dynamically decreased miR-671-5p expression is associated with oncogenic transformation and radiochemoresistance in breast cancer
Background Understanding the molecular alterations associated with breast cancer (BC)
progression may lead to more effective strategies for both prevention and management. The …
progression may lead to more effective strategies for both prevention and management. The …