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Primary biliary cholangitis: pathogenesis and therapeutic opportunities
AF Gulamhusein, GM Hirschfield - Nature Reviews Gastroenterology & …, 2020 - nature.com
Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …
and cholestatic liver disease, which has a variable rate of progression towards biliary …
Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Healthcare is undergoing a transformation, and it is imperative to leverage new technologies
to generate new data and support the advent of precision medicine (PM). Recent scientific …
to generate new data and support the advent of precision medicine (PM). Recent scientific …
[PDF][PDF] Optimal threshold of controlled attenuation parameter with MRI‐PDFF as the gold standard for the detection of hepatic steatosis
C Caussy, MH Alquiraish, P Nguyen… - …, 2018 - Wiley Online Library
The optimal threshold of controlled attenuation parameter (CAP) for the detection of hepatic
steatosis using both M and XL probe is unknown in nonalcoholic fatty liver disease (NAFLD) …
steatosis using both M and XL probe is unknown in nonalcoholic fatty liver disease (NAFLD) …
Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
MicroRNAs in liver disease
G Szabo, S Bala - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …
increasing evidence suggests that they have a role in liver pathology. This Review …
[PDF][PDF] Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis
C Roderburg, GW Urban, K Bettermann, M Vucur… - …, 2011 - Wiley Online Library
Liver fibrosis is orchestrated by a complex network of signaling pathways regulating the
deposition of extracellular matrix proteins during fibrogenesis. MicroRNAs (miRNAs) …
deposition of extracellular matrix proteins during fibrogenesis. MicroRNAs (miRNAs) …
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
AJ Schetter, NHH Heegaard, CC Harris - Carcinogenesis, 2010 - academic.oup.com
Chronic inflammation and infection are major causes of cancer. There are continued
improvements to our understanding of the molecular connections between inflammation and …
improvements to our understanding of the molecular connections between inflammation and …
MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation
Y Lu, Y Zhang, N Wang, Z Pan, X Gao, F Zhang… - Circulation, 2010 - ahajournals.org
Background—A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial
electric remodeling associated with profound reduction of L-type Ca2+ current and …
electric remodeling associated with profound reduction of L-type Ca2+ current and …
Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation
T Chiba, H Marusawa, T Ushijima - Gastroenterology, 2012 - Elsevier
Chronic inflammation, regardless of infectious agents, plays important roles in the
development of various cancers, particularly in digestive organs, including Helicobacter …
development of various cancers, particularly in digestive organs, including Helicobacter …
MiR‐122 modification enhances the therapeutic efficacy of adipose tissue‐derived mesenchymal stem cells against liver fibrosis
G Lou, Y Yang, F Liu, B Ye, Z Chen… - Journal of cellular …, 2017 - Wiley Online Library
Mesenchymal stem cell (MSC) transplantation alone may be insufficient for treatment of liver
fibrosis because of complicated histopathological changes in the liver. Given that miR‐122 …
fibrosis because of complicated histopathological changes in the liver. Given that miR‐122 …