Primary biliary cholangitis: pathogenesis and therapeutic opportunities

AF Gulamhusein, GM Hirschfield - Nature Reviews Gastroenterology & …, 2020 - nature.com
Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …

Are innovation and new technologies in precision medicine paving a new era in patients centric care?

AA Seyhan, C Carini - Journal of translational medicine, 2019 - Springer
Healthcare is undergoing a transformation, and it is imperative to leverage new technologies
to generate new data and support the advent of precision medicine (PM). Recent scientific …

[PDF][PDF] Optimal threshold of controlled attenuation parameter with MRI‐PDFF as the gold standard for the detection of hepatic steatosis

C Caussy, MH Alquiraish, P Nguyen… - …, 2018 - Wiley Online Library
The optimal threshold of controlled attenuation parameter (CAP) for the detection of hepatic
steatosis using both M and XL probe is unknown in nonalcoholic fatty liver disease (NAFLD) …

Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation

A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …

MicroRNAs in liver disease

G Szabo, S Bala - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …

[PDF][PDF] Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis

C Roderburg, GW Urban, K Bettermann, M Vucur… - …, 2011 - Wiley Online Library
Liver fibrosis is orchestrated by a complex network of signaling pathways regulating the
deposition of extracellular matrix proteins during fibrogenesis. MicroRNAs (miRNAs) …

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways

AJ Schetter, NHH Heegaard, CC Harris - Carcinogenesis, 2010 - academic.oup.com
Chronic inflammation and infection are major causes of cancer. There are continued
improvements to our understanding of the molecular connections between inflammation and …

MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation

Y Lu, Y Zhang, N Wang, Z Pan, X Gao, F Zhang… - Circulation, 2010 - ahajournals.org
Background—A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial
electric remodeling associated with profound reduction of L-type Ca2+ current and …

Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation

T Chiba, H Marusawa, T Ushijima - Gastroenterology, 2012 - Elsevier
Chronic inflammation, regardless of infectious agents, plays important roles in the
development of various cancers, particularly in digestive organs, including Helicobacter …

MiR‐122 modification enhances the therapeutic efficacy of adipose tissue‐derived mesenchymal stem cells against liver fibrosis

G Lou, Y Yang, F Liu, B Ye, Z Chen… - Journal of cellular …, 2017 - Wiley Online Library
Mesenchymal stem cell (MSC) transplantation alone may be insufficient for treatment of liver
fibrosis because of complicated histopathological changes in the liver. Given that miR‐122 …