Explaining dopamine through prediction errors and beyond
The most influential account of phasic dopamine holds that it reports reward prediction
errors (RPEs). The RPE-based interpretation of dopamine signaling is, in its original form …
errors (RPEs). The RPE-based interpretation of dopamine signaling is, in its original form …
Forgetting as a form of adaptive engram cell plasticity
One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …
Dopamine: the neuromodulator of long-term synaptic plasticity, reward and movement control
Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions
including motor control, modulation of affective and emotional states, reward mechanisms …
including motor control, modulation of affective and emotional states, reward mechanisms …
Behavioural and dopaminergic signatures of resilience
Chronic stress can have lasting adverse consequences in some individuals, yet others are
resilient to the same stressor,. Susceptible and resilient individuals exhibit differences in the …
resilient to the same stressor,. Susceptible and resilient individuals exhibit differences in the …
A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction
O Gunduz-Cinar, LI Castillo, M ** representations of food and social stimuli in mouse VTA dopamine neurons
Dopamine neurons of the ventral tegmental area (VTA DA) respond to food and social
stimuli and contribute to both forms of motivation. However, it is unclear whether the same or …
stimuli and contribute to both forms of motivation. However, it is unclear whether the same or …
Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala
Extinction memory retrieval is influenced by spatial contextual information that determines
responding to conditioned stimuli (CS). However, it is poorly understood whether contextual …
responding to conditioned stimuli (CS). However, it is poorly understood whether contextual …
Dopamine, updated: reward prediction error and beyond
Highlights•Reward Prediction Error (RPE) remains a compelling theory accounting for VTA
dopamine neuron activity•RPE theory now incorporates sensory prediction errors …
dopamine neuron activity•RPE theory now incorporates sensory prediction errors …
Mesoaccumbal dopamine heterogeneity: what do dopamine firing and release have to do with it?
Ventral tegmental area (VTA) dopamine (DA) neurons are often thought to uniformly encode
reward prediction errors. Conversely, DA release in the nucleus accumbens (NAc), the …
reward prediction errors. Conversely, DA release in the nucleus accumbens (NAc), the …