Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours

C Horbinski, T Berger, RJ Packer, PY Wen - Nature Reviews Neurology, 2022 - nature.com
A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …

EANO guideline on the diagnosis and management of meningiomas

R Goldbrunner, P Stavrinou, MD Jenkinson… - Neuro …, 2021 - academic.oup.com
Meningiomas are the most common intracranial tumors. Yet, only few controlled clinical trials
have been conducted to guide clinical decision making, resulting in variations of …

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

A Choudhury, ST Magill, CD Eaton, BC Prager… - Nature …, 2022 - nature.com
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …

A clinically applicable integrative molecular classification of meningiomas

F Nassiri, J Liu, V Patil, Y Mamatjan, JZ Wang… - Nature, 2021 - nature.com
Meningiomas are the most common primary intracranial tumour in adults. Patients with
symptoms are generally treated with surgery as there are no effective medical therapies. The …

Sarcoma classification by DNA methylation profiling

C Koelsche, D Schrimpf, D Stichel, M Sill… - Nature …, 2021 - nature.com
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some …

DNA methylation profiling: an emerging paradigm for cancer diagnosis

A Papanicolau-Sengos, K Aldape - Annual Review of Pathology …, 2022 - annualreviews.org
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

The WHO 2021 Classification of Central Nervous System tumours: a practical update on what neurosurgeons need to know—a minireview

SH Torp, O Solheim, AJ Skjulsvik - Acta Neurochirurgica, 2022 - Springer
Abstract Background The World Health Organization (WHO) Classification of Tumours, also
known as WHO Blue Books, represents an international standardised tool in the diagnostic …

Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma

JZ Wang, V Patil, AP Landry, C Gui, A Ajisebutu, J Liu… - Nature medicine, 2024 - nature.com
Abstract Treatment of the tumor and dural margin with surgery and sometimes radiation are
cornerstones of therapy for meningioma. Molecular classifications have provided insights …

Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated

SLN Maas, D Stichel, T Hielscher, P Sievers… - Journal of clinical …, 2021 - ascopubs.org
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …

Meningioma: a review of epidemiology, pathology, diagnosis, treatment, and future directions

C Ogasawara, BD Philbrick, DC Adamson - Biomedicines, 2021 - mdpi.com
Meningiomas are the most common intracranial tumor, making up more than a third of all
primary central nervous system (CNS) tumors. They are mostly benign tumors that can be …