Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …

Obesity is defined as the excessive accumulation of body fat and is associated with an
increased risk of develo** major health problems such as cardiovascular disease …

In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the “non‐
feminizing” estrogen, 17‐α‐estradiol (17aE2), extended median male lifespan by 19%(p< …

Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …

Classical evolutionary theories propose tradeoffs among reproduction, damage repair and
lifespan. However, the specific role of the germline in sha** vertebrate aging remains …

The liver and the reproductive system interact in a multifaceted bidirectional fashion. Sex
steroid signaling influences hepatic endobiotic and xenobiotic metabolism and contributes …

To follow‐up on our previous report that acarbose (ACA), a drug that blocks postprandial
glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the …

Abstract Calorie restriction (CR)(25–40%) is the most commonly studied strategy for
curtailing age-related disease and has also been found to extend reproductive lifespan in …

Aging manifests as progressive deteriorations in homeostasis, requiring systems-level
perspectives to investigate the gradual molecular dysregulation of underlying biological …