[HTML][HTML] Magnetic iron oxide nanoparticles for brain imaging and drug delivery
Central nervous system (CNS) disorders affect as many as 1.5 billion people globally. The
limited delivery of most imaging and therapeutic agents into the brain is a major challenge …
limited delivery of most imaging and therapeutic agents into the brain is a major challenge …
Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases
Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …
Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier
Microbubble-enhanced ultrasound provides a noninvasive physical method to locally
overcome major obstacles to the accumulation of blood-borne therapeutics in the brain …
overcome major obstacles to the accumulation of blood-borne therapeutics in the brain …
Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system
The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
Gene therapy for the CNS using AAVs: the impact of systemic delivery by AAV9
Several attempts have been made to discover the ideal vector for gene therapy in central
nervous system (CNS). Adeno-associated viruses (AAVs) are currently the preferred vehicle …
nervous system (CNS). Adeno-associated viruses (AAVs) are currently the preferred vehicle …
Theranostic strategy of focused ultrasound induced blood-brain barrier opening for CNS disease treatment
Focused Ultrasound (FUS) in combination with gaseous microbubbles has emerged as a
potential new means of effective drug delivery to the brain. Recent research has shown that …
potential new means of effective drug delivery to the brain. Recent research has shown that …
[HTML][HTML] State-of-the-art of microbubble-assisted blood-brain barrier disruption
Focused ultrasound with microbubbles promises unprecedented advantages for blood-brain
barrier disruption over existing intracranial drug delivery methods, as well as a significant …
barrier disruption over existing intracranial drug delivery methods, as well as a significant …
[HTML][HTML] Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients
Rationale: Bilateral sonication with focused ultrasound (FUS) in conjunction with
microbubbles has been shown to separately reduce amyloid plaques and …
microbubbles has been shown to separately reduce amyloid plaques and …
Long-term safety of repeated blood-brain barrier opening via focused ultrasound with microbubbles in non-human primates performing a cognitive task
Focused Ultrasound (FUS) coupled with intravenous administration of microbubbles (MB) is
a non-invasive technique that has been shown to reliably open (increase the permeability …
a non-invasive technique that has been shown to reliably open (increase the permeability …