The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

In 2006, humans with a congenital insensitivity to pain (CIP) were found to lack functional
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …

Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …

The concept of pain encompasses a complex interplay of sensory and emotional
experiences associated with actual or potential tissue damage. Accurately describing and …

Abstract Development of therapeutic agents that have fewer adverse effects and have higher
efficacy for diseases, such as cancer, metabolic disorders, neurological diseases, infections …

Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that
exhibit unique pharmacological properties to modulate key membrane protein targets …

Chronic pain is a serious debilitating condition that affects; 20% of the world's population.
Currently available drugs fail to produce effective pain relief in many patients and have dose …

Sea anemone venoms have long been recognized as a rich source of peptides with
interesting pharmacological and structural properties, but they still contain many …

Identification of voltage-gated sodium channel NaV1. 7 inhibitors for chronic pain
therapeutic development is an area of vigorous pursuit. In an effort to identify more potent …

Introduction: Spider venoms are a unique source of bioactive peptides, many of which
display remarkable biological stability and neuroactivity. Phoneutria nigriventer, often …