The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …

By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

Organoids, which are miniature in vitro versions of organs, possess significant potential for
studying human diseases and elucidating their underlying mechanisms. Live imaging …

Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and
functionality of human organs on a microfluidic chip, is undergoing significant technological …

Organoids recapitulate many aspects of the complex three-dimensional (3D) organization
found within native tissues and even display tissue and organ-level functionality. Traditional …

Cell proliferation is a central process in tissue development, homeostasis, and disease, yet
how proliferation is regulated in the tissue context remains poorly understood. Here, we …

Deep learning is emerging as a powerful approach for bioimage analysis. Its use in cell
tracking is limited by the scarcity of annotated data for the training of deep-learning models …

During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

The intestine performs functions central to human health by breaking down food and
absorbing nutrients while maintaining a selective barrier against the intestinal microbiome …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …