Obesity is an epidemic and a public health threat. Medical weight management remains one
of the options for the treatment of excess weight and recent advances have revolutionized …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Adiponectin is an adipose tissue–secreted endogenous insulin sensitizer, which plays a key
role as a mediator of peroxisome proliferator-activated receptor γ action. Adiponectin alters …

Incretin receptor agonists have revolutionized the treatment of obesity, achieving up to 15–
25% weight loss in many patients, ie, at a rate approaching that achieved with bariatric …

The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

Mutations in the human melanocortin (MC) 4 receptor have been associated with obesity,
which underscores the relevance of this receptor as a drug target to treat obesity. Infusion of …

Adiponectin and its receptors play an important role in energy homeostasis and insulin
resistance, but their regulation remains to be fully elucidated. We hypothesized that high-fat …

Leptin is a principal adipose-derived hormone mostly implicated in the regulation of energy
balance through the activation of anorexigenic neuronal pathways. Comprehensive studies …

Melanocortin-4 receptor (MC4R) is critical for energy homeostasis, and the paraventricular
nucleus of the hypothalamus (PVN) is a key site of MC4R action. Most studies suggest that …