Myogenic cells in the body of vertebrates derive from the dorsal somite, the dermomyotome,
where multipotent cells are present. Regulation of cell fate choice is discussed, as is that of …

Mutations in the transcription factor genes FOXE3, HSF4, MAF, and PITX3 cause congenital
lens defects including cataracts that may be accompanied by defects in other components of …

Grafts of foetal ventral mesencephalon, used in cell replacement therapy for Parkinson's
disease, are known to contain a mix of dopamine neuronal subtypes including the A9 …

Expression of the pro-opiomelanocortin (POMC) gene integrates numerous inputs that
reflect the developmental history of POMC-expressing cells of the pituitary and …

During development, major metabolic changes occur as cells become more specialized
within a lineage. In the case of skeletal muscle, differentiation is accompanied by a switch …

The Pleiades Promoter Project integrates genomewide bioinformatics with large-scale
knockin mouse production and histological examination of expression patterns to develop …

The MyoD gene is part of the core regulatory network that governs skeletal myogenesis and
acts as an essential determinant of the myogenic cell fate. Although generic regulatory …

Limbs develop using a common genetic programme despite widely differing morphologies.
This programme is modulated by limb-restricted regulators such as hindlimb (HL) …

Pitx2 is a paired-related homeobox gene that is expressed in muscle progenitors during
myogenesis. We have previously demonstrated that overexpression of Pitx2c isoform in …

Daily adaptation of metabolic activity to light-dark cycles to maintain homeostasis is
controlled by hypothalamic nuclei receiving information from the retina and from nutritional …