Regulation of short-chain fatty acids in the immune system

XF Liu, JH Shao, YT Liao, LN Wang, Y Jia… - Frontiers in …, 2023 - frontiersin.org
A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role …

Obesity as a risk factor for COVID-19: an overview

RW Alberca, LM Oliveira, ACCC Branco… - Critical reviews in …, 2021 - Taylor & Francis
The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for
health-care systems worldwide. Many different risk factors are associated with disease …

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

M Depner, DH Taft, PV Kirjavainen, KM Kalanetra… - Nature medicine, 2020 - nature.com
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …

The causality between intestinal flora and allergic diseases: Insights from a bi-directional two-sample Mendelian randomization analysis

Q **, F Ren, D Dai, N Sun, Y Qian, P Song - Frontiers in immunology, 2023 - frontiersin.org
Background Growing evidence shows a significant association between intestinal flora and
allergic diseases, specifically atopic dermatitis (AD), allergic rhinitis (AR), and allergic …

Adjunctive probiotics alleviates asthmatic symptoms via modulating the gut microbiome and serum metabolome

A Liu, T Ma, N Xu, H **, F Zhao, LY Kwok… - Microbiology …, 2021 - journals.asm.org
Asthma is a multifactorial disorder, and microbial dysbiosis enhances lung inflammation and
asthma-related symptoms. Probiotics have shown anti-inflammatory effects and could …

Perinatal and early-life nutrition, epigenetics, and allergy

N Acevedo, B Alashkar Alhamwe, L Caraballo, M Ding… - Nutrients, 2021 - mdpi.com
Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …

Butyrate shapes immune cell fate and function in allergic asthma

W Yip, MR Hughes, Y Li, A Cait, M Hirst… - Frontiers in …, 2021 - frontiersin.org
The microbiome plays a fundamental role in how the immune system develops and how
inflammatory responses are shaped and regulated. The “gut-lung axis” is a relatively new …

Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression

Q Liu, X Tian, D Maruyama… - American Journal of …, 2021 - journals.physiology.org
Microbial metabolites produced by the gut microbiome, eg short-chain fatty acids (SCFA),
have been found to influence lung physiology and injury responses. However, how lung …

The role of gut microbiota in lung cancer: from carcinogenesis to immunotherapy

X Liu, Y Cheng, D Zang, M Zhang, X Li, D Liu… - Frontiers in …, 2021 - frontiersin.org
The influence of microbiota on host health and disease has attracted adequate attention,
and gut microbiota components and microbiota-derived metabolites affect host immune …

microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis

F Ahangari, NL Price, S Malik, M Chioccioli… - JCI …, 2023 - pmc.ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Recent
findings have shown a marked metabolic reprogramming associated with changes in …