[HTML][HTML] Progress in multicellular human cardiac organoids for clinical applications

H Kim, RD Kamm, G Vunjak-Novakovic, JC Wu - Cell Stem Cell, 2022 - cell.com
Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Autism genes converge on asynchronous development of shared neuron classes

B Paulsen, S Velasco, AJ Kedaigle, M Pigoni… - Nature, 2022 - nature.com
Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes
spanning a wide range of biological functions,,,,–. The alterations in the human brain …

Cell types of the human retina and its organoids at single-cell resolution

CS Cowan, M Renner, M De Gennaro, B Gross-Scherf… - Cell, 2020 - cell.com
Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks

KC Kasuba, AP Buccino, J Bartram, BM Gaub… - Nature …, 2024 - nature.com
A growing consensus that the brain is a mechanosensitive organ is driving the need for tools
that mechanically stimulate and simultaneously record the electrophysiological response of …

A high-density 1,024-channel probe for brain-wide recordings in non-human primates

Y Liu, H Jia, H Sun, S Jia, Z Yang, A Li, A Jiang… - Nature …, 2024 - nature.com
Large-scale neural population recordings with single-cell resolution across the primate brain
remain challenging. Here we introduce the Neuroscroll probe that isolates single neuronal …

Human neuronal maturation comes of age: cellular mechanisms and species differences

JL Wallace, AA Pollen - Nature Reviews Neuroscience, 2024 - nature.com
The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …

SpikeInterface, a unified framework for spike sorting

AP Buccino, CL Hurwitz, S Garcia, J Magland… - Elife, 2020 - elifesciences.org
Much development has been directed toward improving the performance and automation of
spike sorting. This continuous development, while essential, has contributed to an over …

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

H Shin, S Jeong, JH Lee, W Sun, N Choi… - Nature communications, 2021 - nature.com
Investigation of neural circuit dynamics is crucial for deciphering the functional connections
among regions of the brain and understanding the mechanism of brain dysfunction. Despite …

Organic Bioelectronics for In Vitro Systems

C Pitsalidis, AM Pappa, AJ Boys, Y Fu… - Chemical …, 2021 - ACS Publications
Bioelectronics have made strides in improving clinical diagnostics and precision medicine.
The potential of bioelectronics for bidirectional interfacing with biology through continuous …