In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation–
contraction and also excitation–transcription coupling. Its activity can be regulated in …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Rationale: Although research suggests that diastolic Ca2+ levels might be increased in atrial
fibrillation (AF), this hypothesis has never been tested. Diastolic Ca2+ leak from the …

Acute and chronic injuries to the heart result in perturbation of intracellular calcium
signaling, which leads to pathological cardiac hypertrophy and remodeling …

Background—Hemodynamic load regulates myocardial function and gene expression. We
tested the hypothesis that afterload and preload, despite similar average load, result in …

Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in
the pathogenesis of heart failure (HF). However, the specific molecular causes underlying …

Objectives: We investigated changes in Na+ currents (INa) in permanent (or chronic) atrial
fibrillation (AF) and the effects of INainhibition using ranolazine (Ran) on arrhythmias and …

MicroRNAs are small endogenous noncoding RNAs that regulate protein expression by
hybridization to imprecise complementary sequences of target mRNAs. Changes in …

The multifunctional Ca2+-and calmodulin-dependent protein kinase II (CaMKII) is now
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …

Rationale: Heart failure (HF) is known to be associated with increased Ca2+/calmodulin-
dependent protein kinase (CaMK) II expression and activity. There is still controversial …