Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Neurohybrid memristive CMOS-integrated systems for biosensors and neuroprosthetics

A Mikhaylov, A Pimashkin, Y Pigareva… - Frontiers in …, 2020 - frontiersin.org
Here we provide a perspective concept of neurohybrid memristive chip based on the
combination of living neural networks cultivated in microfluidic/microelectrode system, metal …

Induced pluripotent stem cells for treatment of Alzheimer's and Parkinson's diseases

DA Yefroyev, S ** - Biomedicines, 2022 - mdpi.com
Neurodegenerative diseases are a group of debilitating pathologies in which neuronal
tissue dies due to the buildup of neurotoxic plaques, resulting in detrimental effects on …

Electrical stimulation of neural-differentiating iPSCs on novel coaxial electroconductive nanofibers

FFF Garrudo, DES Nogueira, CAV Rodrigues… - Biomaterials …, 2021 - pubs.rsc.org
Neural tissue engineering strategies are paramount to create fully mature neurons,
necessary for new therapeutic strategies for neurological diseases or the creation of reliable …

[HTML][HTML] Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays

J Duru, B Maurer, CG Doran, R Jelitto, J Küchler… - Biosensors and …, 2023 - Elsevier
Bottom-up neuroscience utilizes small, engineered biological neural networks to study
neuronal activity in systems of reduced complexity. We present a platform that establishes …

Novel approaches to the establishment of local microenvironment from resorbable biomaterials in the brain in vitro models

NA Kolotyeva, FN Gilmiyarova, AS Averchuk… - International Journal of …, 2023 - mdpi.com
The development of brain in vitro models requires the application of novel biocompatible
materials and biopolymers as scaffolds for controllable and effective cell growth and …

Toward closed-loop electrical stimulation of neuronal systems: a review

JMA Tanskanen, A Ahtiainen, JAK Hyttinen - Bioelectricity, 2020 - liebertpub.com
Biological neuronal cells communicate using neurochemistry and electrical signals. The
same phenomena also allow us to probe and manipulate neuronal systems and …

Polydimethylsiloxane microfluidic films for in vitro engineering of small-scale neuronal networks

T Takemuro, H Yamamoto, S Sato… - Japanese Journal of …, 2020 - iopscience.iop.org
Polydimethylsiloxane microfluidic devices have become standard tools in cell engineering
research. However, through-holes where cells access the microchannels are usually …

Scaffold in tissue engineering for neuroregeneration and neural repair following traumatic brain injury: A review

YY Wiwoho, N Ibrahim - Indonesian Journal of Neurosurgery, 2024 - ina-jns.org
Background: Traumatic brain injury (TBI) is a leading cause of working-age disability
worldwide. Despite efforts to develop neuroprotective treatment approaches, meaningful …

[HTML][HTML] Integration of Immature Neurons Maintain Unidirectional Connectivity of Pre-Existed Network In Vitro

VN Kolpakov, MS Zemlyanskov… - Opera Medica et …, 2022 - cyberleninka.ru
Recovery of the neural networks after brain injury can be studied in vitro using cell
patterning technologies such as microfluidics. In this study, neural tissue recovery of cortical …