Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing
neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by …

The number of therapies for heart failure (HF) with reduced ejection fraction has nearly
doubled in the past decade. In addition, new therapies for HF caused by hypertrophic and …

Sleep is integral to life. Although insufficient or disrupted sleep increases the risk of multiple
pathological conditions, including cardiovascular disease, we know little about the cellular …

In patients with heart failure, the beneficial effects of drug and device therapies counteract to
some extent ongoing cardiac damage. According to the net balance between these two …

Summary Narcolepsy type 1 (NT1) is a lifelong disorder of sleep-wake dysregulation defined
by clinical symptoms, neurophysiological findings, and low hypocretin levels. Besides a role …

Heart failure (HF) is a common clinical condition encountered in various healthcare settings
with a vast socioeconomic impact. Recent advancements in pharmacotherapy have led to …

Background Orexins are two neuropeptides (orexin A, OXA; orexin B, OXB) secreted mainly
from the lateral hypothalamus, which exert a wide range of physiological effects by activating …

Background Observational findings suggest that patients with narcolepsy are at higher risk
for cardiovascular diseases (CVDs), but the potential causal relationship between …

In order to understand the nature of the relationship between cerebral blood flow (CBF) and
primary headaches, we have conducted a literature review with particular emphasis on the …

Simple Summary This narrative review first describes from several points of view the
complex interrelationship between cancer and neurodegeneration, with special attention to …