The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …

Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

The serotonin transporter (SERT) on platelets is a primary mechanism for serotonin (5HT)
uptake from the blood plasma. Alteration in plasma 5HT level is associated with a number of …

The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …

Efflux of dopamine through the dopamine transporter (DAT) is critical for the
psychostimulatory properties of amphetamines, but the underlying mechanism is unclear …

Parkinsonism and attention deficit hyperactivity disorder (ADHD) are widespread brain
disorders that involve disturbances of dopaminergic signaling. The sodium-coupled …

Modulating protein–protein interactions involved in disease pathways is an attractive
strategy for develo** drugs, but remains a challenge to achieve. One approach is to target …

The dopamine transporter (DAT) is crucial for regulating dopamine signalling and is the
prime mediator for the rewarding and addictive effects of cocaine. As part of the …

The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission
through the clearance of dopamine from the extracellular space. Dysregulation of DAT is …