AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice

A Yamagishi, N Yonemochi, A Kimura… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Diabetic patients have an increased risk of psychiatric
disorders. Because hyperglycaemia increases L‐lactate in the brain and L‐lactate inhibits …

Sex differences and role of estradiol in hypoglycemia-associated counter-regulation

KP Briski, HN Alhamami, A Alshamrani… - Sex and Gender Factors …, 2017 - Springer
Vital nerve cell functions, including maintenance of transmembrane voltage and information
transfer, occur at high energy expense. Inadequate provision of the obligate metabolic fuel …

Hindbrain estrogen receptor regulation of ventromedial hypothalamic glycogen metabolism and glucoregulatory transmitter expression in the hypoglycemic male rat

MH Ali, PR Napit, ASMH Mahmood, K Bheemanapally… - Neuroscience, 2019 - Elsevier
Estrogen receptor-alpha (ERα) and-beta (ERβ) occur in key elements of the brain gluco-
homeostatic network in both sexes, including the hindbrain dorsal vagal complex (DVC), but …

Role of hindbrain adenosine 5′-monophosphate-activated protein kinase (AMPK) in hypothalamic AMPK and metabolic neuropeptide adaptation to recurring insulin …

SK Mandal, PK Shrestha, FSH Alenazi, M Shakya… - Neuropeptides, 2017 - Elsevier
Glucose counter-regulatory dysfunction correlates with impaired activation of the
hypothalamic metabolic sensor adenosine 5′-monophosphate-activated protein kinase …

Hindbrain medulla catecholamine cell group involvement in lactate-sensitive hypoglycemia-associated patterns of hypothalamic norepinephrine and epinephrine …

PK Shrestha, P Tamrakar, BA Ibrahim, KP Briski - Neuroscience, 2014 - Elsevier
Cell-type compartmentation of glucose metabolism in the brain involves trafficking of the
oxidizable glycolytic end product, l-lactate, by astrocytes to fuel neuronal mitochondrial …

Diazepam binding inhibitor control of eu-and hypoglycemic patterns of ventromedial hypothalamic nucleus glucose-regulatory signaling

SC Roy, S Sapkota, MB Pasula, K Bheemanapally… - ASN neuro, 2023 - Taylor & Francis
Pharmacological stimulation/antagonism of astrocyte glio-peptide octadecaneuropeptide
signaling alters ventromedial hypothalamic nucleus (VMN) counterregulatory γ-aminobutyric …

Lateral but not medial hypothalamic AMPK activation occurs at the hypoglycemic nadir in insulin-injected male rats: Impact of caudal dorsomedial hindbrain …

HN Alhamami, MM Uddin, ASMH Mahmood, KP Briski - Neuroscience, 2018 - Elsevier
The hypothalamic energy sensor adenosine 5′-monophosphate-activated protein kinase
(AMPK), an important regulator of counter-regulatory responses to hypoglycemia, responds …

Estradiol regulation of hypothalamic astrocyte adenosine 5′-monophosphate-activated protein kinase activity: role of hindbrain catecholamine signaling

P Tamrakar, KP Briski - Brain Research Bulletin, 2015 - Elsevier
Recent work challenges the conventional notion that metabolic monitoring in the brain is the
exclusive function of neurons. This study investigated the hypothesis that hypothalamic …

Glycemic challenge is associated with the rapid cellular activation of the locus ceruleus and nucleus of solitary tract: Circumscribed spatial analysis of phosphorylated …

GP Tapia, LJ Agostinelli, SD Chenausky… - Journal of Clinical …, 2023 - mdpi.com
Rodent studies indicate that impaired glucose utilization or hypoglycemia is associated with
the cellular activation of neurons in the medulla (Winslow, 1733)(MY), believed to control …

Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK, metabolic neuropeptide, and norepinephrine activity and food intake in the female rat

FSH Alenazi, BA Ibrahim, H Al-Hamami, M Shakiya… - Neuroscience, 2016 - Elsevier
This study addressed the hypothesis that dorsomedial hindbrain adenosine 5′-
monophosphate-activated protein kinase (AMPK) imposes inherent estradiol-dependent …