Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …

A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

Mammalian thioredoxin reductase (TrxR) enzymes are homodimeric flavin proteins sharing
a unique yet essential selenocysteine residue at their C‐terminus. TrxRs, together with their …

Auranofin (AF), a gold compound, has been used to treat rheumatoid arthritis (RA) for more
than 40 years; however, its mechanism of action remains unknown. We revealed that AF …

This article provides an overview of the development, structure and activity of various metal
complexes with anti-cancer activity. Chemical researchers continue to work on the …

Owing to the growing hardware capabilities and the enhancing efficacy of computational
methodologies, computational chemistry approaches have constantly become more …

Thioredoxin reductase (TrxR) is a selenoenzyme that could regulate intracellular oxidative
balance and found to be overexpressed in many human tumor cells. Due to its important role …

Due to the increasing incidence and high mortality associated with colorectal cancer (CRC),
novel therapeutic strategies are urgently needed. Classic chemotherapy against CRC is …

Metallodrugs were classically screened against skin cancer (either in vitro or in vivo) at the
peak of the development of platinum anticancer agents. New systematic studies appeared in …