CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Salamanders have been hailed as champions of regeneration, exhibiting a remarkable
ability to regrow tissues, organs and even whole body parts, eg their limbs. As such …

Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated
effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema …

Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …

Parkinson's disease (PD) and other chronic and debilitating neurodegenerative diseases
(NDs) impose a substantial medical, emotional, and financial burden on individuals and …

Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …

The majority of animal phyla have species that can regenerate. Comparing regeneration
across animals can reconstruct the molecular and cellular evolutionary history of this …

Neural stem cells (NSCs) are multipotent progenitors that are responsible for producing all
of the neurons and macroglia in the nervous system. In adult mammals, NSCs reside …

Throughout the animal kingdom regenerative ability varies greatly from species to species,
and even tissue to tissue within the same organism. The sheer diversity of structures and …