Sepsis is characterized as an uncontrolled host response to infection, and it represents a
serious health challenge, causing excess mortality and morbidity worldwide. The discovery …

The ecosystem of the gut microbiota consists of diverse intestinal species with multiple
metabolic and immunologic activities and it is closely connected with the intestinal epithelia …

MicroRNAs are a class of evolutionarily conserved, short non-coding RNAs that post-
transcriptionally modulate the expression of multiple target genes. They are implicated in …

Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a
dysregulated host response to infection and causes millions of deaths worldwide annually …

Introduction MicroRNAs have been found to be of high significance in the regulation of
various genes and processes in the body. Sepsis is a serious clinical problem which arises …

Background Sepsis coincides with altered gene expression in different tissues.
Accumulating evidence has suggested that microRNAs, long non-coding RNAs, and circular …

Sepsis is a life-threating condition with dysregulated systemic host response to microbial
pathogens leading to disproportionate inflammatory response and multi-organ failure …

miRNA-146a, a single-stranded, non-coding RNA molecule, has emerged as a valuable
diagnostic and prognostic biomarker for numerous pathological conditions. Its primary …

The mammalian intestinal tract is a unique site in which a large portion of our immune
system and the 1014 commensal organisms that make up the microbiota reside in intimate …

Sepsis is a systemic inflammatory response syndrome caused by an infection. Toll-like
receptor 4 (TLR4) is activated by endogenous molecules released by injured or necrotic …